Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model
H Motoyama, F Chen, A Ohsumi, K Hijiya… - The Journal of Heart and …, 2013 - Elsevier
BACKGROUND: Donor lung thrombi are considered an important etiology for primary graft
dysfunction in lung transplantation. We hypothesized that thrombolysis before lung
transplantation could alleviate ischemia-reperfusion injury. This study was designed to
evaluate the effect of the fibrinolytic agent plasmin on lungs damaged by thrombi in an ex
vivo lung perfusion (EVLP) system. METHODS: Rats were divided into control, non-plasmin,
and plasmin groups (n= 7 each). In the control and plasmin groups, cardiac arrest was …
dysfunction in lung transplantation. We hypothesized that thrombolysis before lung
transplantation could alleviate ischemia-reperfusion injury. This study was designed to
evaluate the effect of the fibrinolytic agent plasmin on lungs damaged by thrombi in an ex
vivo lung perfusion (EVLP) system. METHODS: Rats were divided into control, non-plasmin,
and plasmin groups (n= 7 each). In the control and plasmin groups, cardiac arrest was …