Graft-versus-host reactions in F1 hybrid mice: MHC-restriction-independent generalized depression of virus-specific cytotoxic T cell response
BC Pestalozzi, RM Zinkernagel - Immunobiology, 1984 - Elsevier
A graft-versus-host reaction (GVHR) was induced in F 1 hybrid mice by intravenous injection
of parental spleen cells. A possible effect generated by recipient F 1 mice of a GVHR on the
restriction specificities of anti-viral cytotoxic T cells was investigated.(A/J× C57BL/6) F 1
recipients were injected with 1× 10 8 or 2× 10 7 spleen cells from either parent. Zero to two
weeks later during an acute GVHR or 12 to 26 weeks later during a chronic GVHR, spleen
cells from these F1 recipients were assayed for their capacity to generate vaccinia (or …
of parental spleen cells. A possible effect generated by recipient F 1 mice of a GVHR on the
restriction specificities of anti-viral cytotoxic T cells was investigated.(A/J× C57BL/6) F 1
recipients were injected with 1× 10 8 or 2× 10 7 spleen cells from either parent. Zero to two
weeks later during an acute GVHR or 12 to 26 weeks later during a chronic GVHR, spleen
cells from these F1 recipients were assayed for their capacity to generate vaccinia (or …