[HTML][HTML] Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants
B Li, MG Hartwig, JZ Appel, EL Bush… - American Journal of …, 2008 - Elsevier
Long-term survival of a pulmonary allograft is currently hampered by obliterative
bronchiolitis (OB), a form of chronic rejection that is unique to lung transplantation. While
tracheobronchial aspiration from gastroesophageal reflux disease (GERD) has clinically
been associated with OB, no experimental model exists to investigate this problem. Using a
WKY-to-F344 rat orthotopic left lung transplant model, the effects of chronic aspiration on
pulmonary allograft were evaluated. Recipients received cyclosporine with or without 8 …
bronchiolitis (OB), a form of chronic rejection that is unique to lung transplantation. While
tracheobronchial aspiration from gastroesophageal reflux disease (GERD) has clinically
been associated with OB, no experimental model exists to investigate this problem. Using a
WKY-to-F344 rat orthotopic left lung transplant model, the effects of chronic aspiration on
pulmonary allograft were evaluated. Recipients received cyclosporine with or without 8 …