[HTML][HTML] Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from

A Bhandoola, H von Boehmer, HT Petrie… - Immunity, 2007 - cell.com
Immunity, 2007cell.com
T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the
bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to
intrathymic T lineage-committed progenitors is important for understanding cancer in T
lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-
therapy approaches to treat defective T cell development or function. Such an understanding
may also help ameliorate immunological defects in aging. This review covers the …
T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus.
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