Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25

K Gossens, S Naus, SY Corbel, S Lin… - Journal of Experimental …, 2009 - rupress.org
K Gossens, S Naus, SY Corbel, S Lin, FMV Rossi, J Kast, HJ Ziltener
Journal of Experimental Medicine, 2009rupress.org
Thymic T cell progenitor (TCP) importation is a periodic, gated event that is dependent on
the expression of functional P-selectin ligands on TCPs. Occupancy of intrathymic TCP
niches is believed to negatively regulate TCP importation, but the nature of this feedback
mechanism is not yet resolved. We show that P-selectin and CCL25 are periodically
expressed in the thymus and are essential parts of the thymic gate-keeping mechanism.
Periodicity of thymic TCP receptivity and the size of the earliest intrathymic TCP pool were …
Thymic T cell progenitor (TCP) importation is a periodic, gated event that is dependent on the expression of functional P-selectin ligands on TCPs. Occupancy of intrathymic TCP niches is believed to negatively regulate TCP importation, but the nature of this feedback mechanism is not yet resolved. We show that P-selectin and CCL25 are periodically expressed in the thymus and are essential parts of the thymic gate-keeping mechanism. Periodicity of thymic TCP receptivity and the size of the earliest intrathymic TCP pool were dependent on the presence of functional P-selectin ligand on TCPs. Furthermore, we show that the numbers of peripheral blood lymphocytes directly affected thymic P-selectin expression and TCP receptivity. We identified sphingosine-1-phosphate (S1P) as one feedback signal that could mediate influence of the peripheral lymphocyte pool on thymic TCP receptivity. Our findings suggest a model whereby thymic TCP importation is controlled by both early thymic niche occupancy and the peripheral lymphocyte pool via S1P.
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