[HTML][HTML] Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response
A Paun, JT Reinert, Z Jiang, C Medin, MY Balkhi… - Journal of Biological …, 2008 - ASBMB
Although the role of human IRF-5 in antiviral and inflammatory responses in vitro has been
well characterized, much remains to be elucidated about murine IRF-5. Murine IRF-5, unlike
the heavily spliced human gene, is primarily expressed as a full-length transcript, with only a
single splice variant that was detected in very low levels in the bone marrow of C57BL/6J
mice. This bone marrow variant contains a 288-nucleotide deletion from exons 4–6 and
exhibits impaired transcriptional activity. The murine IRF-5 can be activated by both TBK1 …
well characterized, much remains to be elucidated about murine IRF-5. Murine IRF-5, unlike
the heavily spliced human gene, is primarily expressed as a full-length transcript, with only a
single splice variant that was detected in very low levels in the bone marrow of C57BL/6J
mice. This bone marrow variant contains a 288-nucleotide deletion from exons 4–6 and
exhibits impaired transcriptional activity. The murine IRF-5 can be activated by both TBK1 …