TH 1/TH 2 lymphocytes: doubt some more

L Borish, L Rosenwasser - Journal of allergy and clinical immunology, 1997 - jacionline.org
The concept of T helper lymphocyte heterogeneity with T,~ and TH2 subclasses, which can
be distinguished on the basis of their cytokine repertoire, has been a useful paradigm in
studies on the immunology of allergic disorders? T m cells are generally defined by their
synthesis of IL-2, interferon (IFN)--/, and tumor necrosis factor-J3 and are involved in cellular
immunity; whereas T. 2 cells are reported to produce IL-4, IL-5, IL-9, IL-10, and IL-13 and are
involved in humoral immune responses and allergy. This paradigm has led to the concept …