Background A small population of patients with severe asthma does not respond to
glucocorticoids (steroid resistant [SR]). They have high morbidity, highlighting an urgent
need for strategies to enhance glucocorticoid responsiveness. Objective We investigated the
immunologic differences between steroid-sensitive (SS) and SR asthmatic patients and the
effect on immunophenotype of oral calcitriol treatment because it has been previously
shown to beneficially modulate the clinical response to glucocorticoids in patients with SR …