[HTML][HTML] Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells
F Lalanne, G Lambert, MJA Amar, M Chétiveaux… - Journal of lipid …, 2005 - ASBMB
Mutations in Proprotein Convertase Subtilisin Kexin 9 (PCSK9) have been associated with
autosomal dominant hypercholesterolemia. In vivo kinetic studies indicate that LDL
catabolism was impaired and apolipoprotein B (apoB)-containing lipoprotein synthesis was
enhanced in two patients presenting with the S127R mutation on PCSK9. To understand the
physiological role of PCSK9, we overexpressed human PCSK9 in mouse and cellular
models as well as attenuated the endogenous expression of PCSK9 in HuH7 hepatoma …
autosomal dominant hypercholesterolemia. In vivo kinetic studies indicate that LDL
catabolism was impaired and apolipoprotein B (apoB)-containing lipoprotein synthesis was
enhanced in two patients presenting with the S127R mutation on PCSK9. To understand the
physiological role of PCSK9, we overexpressed human PCSK9 in mouse and cellular
models as well as attenuated the endogenous expression of PCSK9 in HuH7 hepatoma …