[HTML][HTML] Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression
RA Parker, R Garcia, CS Ryan, X Liu, P Shipkova… - Journal of lipid …, 2013 - ASBMB
Proprotein convertase subtilisin-kexin-9 (PCSK9) inhibition markedly augments the LDL
lowering action of statins. The combination is being evaluated for long-term effects on
atherosclerotic disease outcomes. However, effects of combined treatment on hepatic
cholesterol and bile acid metabolism have not yet been reported. To study this, PCSK9-
Y119X mutant (knockout) and wild-type mice were treated with or without atorvastatin for 12
weeks. Atorvastatin progressively lowered plasma LDL in each group, but no differences in …
lowering action of statins. The combination is being evaluated for long-term effects on
atherosclerotic disease outcomes. However, effects of combined treatment on hepatic
cholesterol and bile acid metabolism have not yet been reported. To study this, PCSK9-
Y119X mutant (knockout) and wild-type mice were treated with or without atorvastatin for 12
weeks. Atorvastatin progressively lowered plasma LDL in each group, but no differences in …