[HTML][HTML] Sodium channel β1 subunits promote neurite outgrowth in cerebellar granule neurons
Many immunoglobulin superfamily members are integral in development through regulation
of processes such as growth cone guidance, cell migration, and neurite outgrowth. We
demonstrate that homophilic interactions between voltage-gated sodium channel β1
subunits promote neurite extension in cerebellar granule neurons. Neurons isolated from
wild-type or β1 (-/-) mice were plated on top of parental, mock-, or β1-transfected fibroblasts.
Wild-type neurons consistently showed increased neurite length when grown on β1 …
of processes such as growth cone guidance, cell migration, and neurite outgrowth. We
demonstrate that homophilic interactions between voltage-gated sodium channel β1
subunits promote neurite extension in cerebellar granule neurons. Neurons isolated from
wild-type or β1 (-/-) mice were plated on top of parental, mock-, or β1-transfected fibroblasts.
Wild-type neurons consistently showed increased neurite length when grown on β1 …