[HTML][HTML] CD28 negative T cells: is their loss our gain?
D Mou, J Espinosa, DJ Lo, AD Kirk - American Journal of Transplantation, 2014 - Elsevier
CD28 is a primary costimulation molecule for T cell activation. However, during the course of
activation some T cells lose this molecule and assume a CD28-independent existence.
These CD28− T cells are generally antigen-experienced and highly differentiated. CD28− T
cells are functionally heterogeneous. Their characteristics vary largely on the context in
which they are found and range from having enhanced cytotoxic abilities to promoting
immune regulation. Thus, CD28 loss appears to be more of a marker for advanced …
activation some T cells lose this molecule and assume a CD28-independent existence.
These CD28− T cells are generally antigen-experienced and highly differentiated. CD28− T
cells are functionally heterogeneous. Their characteristics vary largely on the context in
which they are found and range from having enhanced cytotoxic abilities to promoting
immune regulation. Thus, CD28 loss appears to be more of a marker for advanced …