[HTML][HTML] Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms

SS Shen, B Krishna, R Chirala, RJ Amato, LD Truong - Modern pathology, 2005 - Elsevier
Renal cell neoplasms are presumably derived from different cell types of the nephron. Clear
cell and papillary renal cell carcinoma (RCC) are thought to be of proximal tubular origin,
whereas oncocytoma and chromophobe RCC are derived from intercalated cells of distal
nephron. A few molecules, such as RCC marker and CD10, have been shown to be markers
for clear cell RCC and papillary RCC. Such markers are not yet available for renal tumors
presumably of the distal nephron. The expression of kidney-specific (Ksp) cadherin, a …