A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis
RL Greenman, RMH Schein, MA Martin, RP Wenzel… - Jama, 1991 - jamanetwork.com
Objective.—To assess the efficacy of adjunctive monoclonal antibody antiendotoxin
immunotherapy in patients with gram-negative sepsis. Design.—Double-blind, randomized,
placebo-controlled trial. Setting.—Thirty-three university-affiliated centers, including
Veterans Affairs, community, and municipal hospitals. Patients.—Hospitalized adults with
signs of gram-negative infection and a systemic septic response. Intervention.—Patients
were assigned to receive either 2 mg/kg of a murine monoclonal antibody directed against …
immunotherapy in patients with gram-negative sepsis. Design.—Double-blind, randomized,
placebo-controlled trial. Setting.—Thirty-three university-affiliated centers, including
Veterans Affairs, community, and municipal hospitals. Patients.—Hospitalized adults with
signs of gram-negative infection and a systemic septic response. Intervention.—Patients
were assigned to receive either 2 mg/kg of a murine monoclonal antibody directed against …