Marrow damage and hematopoietic recovery following allogeneic bone marrow transplantation for acute leukemias: Effect of radiation dose and conditioning regimen
C Wilke, SG Holtan, L Sharkey, T DeFor, M Arora… - Radiotherapy and …, 2016 - Elsevier
Background and purpose Total body irradiation (TBI) is a common component of
hematopoietic cell transplantation (HCT) conditioning regimens. Preclinical studies suggest
prolonged bone marrow (BM) injury after TBI could contribute to impaired engraftment and
poor hematopoietic function. Materials and methods We studied the longitudinal changes in
the marrow environment in patients receiving allogeneic HCT with myeloablative (MA, n=
42) and reduced intensity (RIC, n= 56) doses of TBI from 2003–2013, including BM …
hematopoietic cell transplantation (HCT) conditioning regimens. Preclinical studies suggest
prolonged bone marrow (BM) injury after TBI could contribute to impaired engraftment and
poor hematopoietic function. Materials and methods We studied the longitudinal changes in
the marrow environment in patients receiving allogeneic HCT with myeloablative (MA, n=
42) and reduced intensity (RIC, n= 56) doses of TBI from 2003–2013, including BM …
