[HTML][HTML] ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated …

FG Schaap, PCN Rensen, PJ Voshol, C Vrins… - Journal of biological …, 2004 - ASBMB
ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but
the pathways involved are currently unknown. To gain insight into the function of apoAV,
adenovirus-mediated gene transfer of murine apoa5 to C57Bl/6 mice was employed. The
injection of low doses of Ad-apoa5 (1–5× 10 8 plaqueforming units/mouse) dose-
dependently reduced plasma very low density lipoprotein (VLDL)-TG levels. First, we
evaluated whether a reduced hepatic VLDL production contributed to the TG-lowering effect …