Growth factors affect epithelial regeneration after acute renal injury, but less is known
regarding the expression of vascular growth factors in this setting. A mouse model of folic
acid (FA)-induced nephrotoxicity was used to study the expression of angiopoietins (Ang),
factors that bind the Tie-2 receptor and modulate endothelial growth. Tubular damage was
detected 1 d after FA administration; in the next 14 d, most tubules regenerated but patchy
atrophy, with interstitial fibrosis, was also observed. Ang-1 immunostaining was detected …