Preterm infants lack adequate surfactant production and often require oxygen support for
adequate oxygenation. Prolonged oxygen treatment leads to the development of
bronchopulmonary dysplasia (BPD), a disease process characterized by the blunting of
alveolarization and proliferation of myofibroblasts. In the present study, we investigated
metabolic adaptive changes in cultured fibroblasts isolated from immature (d18) and near-
term (d21), fetal rat lungs in response to normoxic (21%) and hyperoxic (95%) exposures …