Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides
Obesity is associated with increased activity of two lipid signaling systems
(endocannabinoids [ECs] and ceramides), with both being implicated in insulin resistance.
Cannabinoid-1 receptor (CB 1 R) antagonists reverse obesity and insulin resistance, but
have psychiatric side effects. Here we analyzed the role of ceramide in CB 1 R-mediated
insulin resistance in C57Bl6/J mice with high-fat diet-induced obesity (DIO), using JD5037, a
peripherally restricted CB 1 R inverse agonist. Chronic JD5037 treatment of DIO mice …
(endocannabinoids [ECs] and ceramides), with both being implicated in insulin resistance.
Cannabinoid-1 receptor (CB 1 R) antagonists reverse obesity and insulin resistance, but
have psychiatric side effects. Here we analyzed the role of ceramide in CB 1 R-mediated
insulin resistance in C57Bl6/J mice with high-fat diet-induced obesity (DIO), using JD5037, a
peripherally restricted CB 1 R inverse agonist. Chronic JD5037 treatment of DIO mice …