Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin
G Gurujeyalakshmi, Y Wang, SN Giri - Nitric Oxide, 2000 - Elsevier
The effects of taurine (T) and niacin (N) on the influx of inflammatory cells and nitric oxide
(NO) levels in bronchoalveolar lavage fluid (BALF) and expression of inducible NO synthase
(iNOS) mRNA and iNOS protein in lungs were evaluated in the bleomycin (BL)–mouse
model of lung fibrosis. Mice were placed into four groups: saline-instilled (SA) with a control
diet (CD)(SA+ CD); saline-instilled with TN (1% taurine in water+ 2.5%(w/w) niacin in
diet)(SA+ TN); BL-instilled with CD (BL+ CD); and BL-instilled with TN treatment (BL+ TN) …
(NO) levels in bronchoalveolar lavage fluid (BALF) and expression of inducible NO synthase
(iNOS) mRNA and iNOS protein in lungs were evaluated in the bleomycin (BL)–mouse
model of lung fibrosis. Mice were placed into four groups: saline-instilled (SA) with a control
diet (CD)(SA+ CD); saline-instilled with TN (1% taurine in water+ 2.5%(w/w) niacin in
diet)(SA+ TN); BL-instilled with CD (BL+ CD); and BL-instilled with TN treatment (BL+ TN) …