[HTML][HTML] Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-κB independently of platelet-activating …

J Liu, S Bátkai, P Pacher, J Harvey-White… - Journal of Biological …, 2003 - ASBMB
Macrophage-derived endocannabinoids have been implicated in endotoxin
(lipopolysaccharide (LPS))-induced hypotension, but the endocannabinoid involved and the
mechanism of its regulation by LPS are unknown. In RAW264. 7 mouse macrophages, LPS
(10 ng/ml) increases anandamide (AEA) levels> 10-fold via CD14-, NF-κB-, and p44/42-
dependent, platelet-activating factor-independent activation of the AEA biosynthetic
enzymes, N-acyltransferase and phospholipase D. LPS also induces the AEA-degrading …