Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction
DV Pechkovsky, A Prasse, F Kollert, KMY Engel… - Clinical …, 2010 - Elsevier
Activated macrophages have been characterized as M1 and M2 according to their
inflammatory response pattern. Here we analyzed the M2 marker expression and
intracellular signal transduction in the course of cytokine-driven differentiation. We found
elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and
increased expression of CD206 by alveolar macrophages from patients with lung fibrosis.
Stimulation of normal human AM with Th2 cytokines IL-4 and/or IL-10 in vitro revealed IL-4 …
inflammatory response pattern. Here we analyzed the M2 marker expression and
intracellular signal transduction in the course of cytokine-driven differentiation. We found
elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and
increased expression of CD206 by alveolar macrophages from patients with lung fibrosis.
Stimulation of normal human AM with Th2 cytokines IL-4 and/or IL-10 in vitro revealed IL-4 …