β-Adrenoceptor and GRK3 expression in human lymphocytes is related to blood pressure and urinary albumin excretion
E Oliver, E Rovira, F Montó, C Valldecabres… - Journal of …, 2010 - journals.lww.com
E Oliver, E Rovira, F Montó, C Valldecabres, R Julve, V Muedra, N Ruiz, D Barettino…
Journal of hypertension, 2010•journals.lww.comObjective The objective of our work was to analyze if changes in the expression of β-
adrenoceptors (β-ARs) and G-protein-coupled receptor kinases (GRKs) in human
lymphocytes–a practical surrogate for myocardial or vascular cells–are related to the
hypertensive state and its clinical consequences. Methods Real-time quantitative RT-PCR
was employed to evaluate the expression of the three β-ARs (β 1, β 2, β 3) and three GRKs
(GRK2, GRK3, GRK5) in human lymphocytes obtained from both normotensive and …
adrenoceptors (β-ARs) and G-protein-coupled receptor kinases (GRKs) in human
lymphocytes–a practical surrogate for myocardial or vascular cells–are related to the
hypertensive state and its clinical consequences. Methods Real-time quantitative RT-PCR
was employed to evaluate the expression of the three β-ARs (β 1, β 2, β 3) and three GRKs
(GRK2, GRK3, GRK5) in human lymphocytes obtained from both normotensive and …
Abstract
Objective
The objective of our work was to analyze if changes in the expression of β-adrenoceptors (β-ARs) and G-protein-coupled receptor kinases (GRKs) in human lymphocytes–a practical surrogate for myocardial or vascular cells–are related to the hypertensive state and its clinical consequences.
Methods
Real-time quantitative RT-PCR was employed to evaluate the expression of the three β-ARs (β 1, β 2, β 3) and three GRKs (GRK2, GRK3, GRK5) in human lymphocytes obtained from both normotensive and hypertensive patients, some of whom had been treated with blockers of the renin–angiotensin system. Office blood pressure, 24-h ambulatory blood pressure, urinary albumin excretion and serum biochemical profile were also recorded.
Lippincott Williams & Wilkins