Human β-adrenoceptors: relation of myocardial and lymphocyte β-adrenoceptor density
OE Brodde, R Kretsch, K Ikezono, HR Zerkowski… - Science, 1986 - science.org
OE Brodde, R Kretsch, K Ikezono, HR Zerkowski, JC Reidemeister
Science, 1986•science.orgIn human right atria obtained from 21 patients during open-heart surgery, β-adrenoceptor
density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness
(positive inotropic responses to isoprenaline) were linearly related to the β-adrenoceptor
density in the corresponding circulating lymphocytes. This direct relation of human
myocardial and lymphocyte β-adrenoceptor alterations, therefore, makes it possible to
monitor drug-or disease-induced β-adrenoceptor changes in tissues not easily accessible in …
density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness
(positive inotropic responses to isoprenaline) were linearly related to the β-adrenoceptor
density in the corresponding circulating lymphocytes. This direct relation of human
myocardial and lymphocyte β-adrenoceptor alterations, therefore, makes it possible to
monitor drug-or disease-induced β-adrenoceptor changes in tissues not easily accessible in …
In human right atria obtained from 21 patients during open-heart surgery, β-adrenoceptor density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness (positive inotropic responses to isoprenaline) were linearly related to the β-adrenoceptor density in the corresponding circulating lymphocytes. This direct relation of human myocardial and lymphocyte β-adrenoceptor alterations, therefore, makes it possible to monitor drug- or disease-induced β-adrenoceptor changes in tissues not easily accessible in humans.
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