[HTML][HTML] Thermogenic activation induces FGF21 expression and release in brown adipose tissue

E Hondares, R Iglesias, A Giralt, FJ Gonzalez… - Journal of Biological …, 2011 - ASBMB
FGF21 is a novel metabolic regulator involved in the control of glucose homeostasis, insulin
sensitivity, and ketogenesis. The liver has been considered the main site of production and
release of FGF21 into the blood. Here, we show that, after thermogenic activation, brown
adipose tissue becomes a source of systemic FGF21. This is due to a powerful cAMP-
mediated pathway of regulation of FGF21 gene transcription. Norepinephrine, acting via β-
adrenergic, cAMP-mediated, mechanisms and subsequent activation of protein kinase A …