[PDF][PDF] Pleiotropic roles of bile acids in metabolism

TQ de Aguiar Vallim, EJ Tarling, PA Edwards - Cell metabolism, 2013 - cell.com
TQ de Aguiar Vallim, EJ Tarling, PA Edwards
Cell metabolism, 2013cell.com
Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that
activate four distinct receptors. Activation of these receptors alters gene expression in
multiple tissues, leading to changes not only in bile acid metabolism but also in glucose
homeostasis, lipid and lipoprotein metabolism, energy expenditure, intestinal motility and
bacterial growth, inflammation, liver regeneration, and hepatocarcinogenesis. This review …
Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that activate four distinct receptors. Activation of these receptors alters gene expression in multiple tissues, leading to changes not only in bile acid metabolism but also in glucose homeostasis, lipid and lipoprotein metabolism, energy expenditure, intestinal motility and bacterial growth, inflammation, liver regeneration, and hepatocarcinogenesis. This review covers the roles of specific bile acids, synthetic agonists, and their cognate receptors in controlling these diverse functions, as well as their current use in treating human diseases.
cell.com