Identification of a major co-receptor for primary isolates of HIV-1

HK Deng, R Liu, W Ellmeier, S Choe, D Unutmaz… - Nature, 1996 - nature.com
HK Deng, R Liu, W Ellmeier, S Choe, D Unutmaz, M Burkhart, PD Marzio, S Marmon
Nature, 1996nature.com
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A
cofactor required for infection with virus adapted for growth in transformed T-cell lines was
recently identified and named fusin. However, fusin does not promote entry of macrophage-
tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal
cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic
strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP …
Abstract
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.
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