[HTML][HTML] Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

GS Hotamisligil - Cell, 2010 - cell.com
Cell, 2010cell.com
The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking
and is central to many cellular functions. Failure of the ER's adaptive capacity results in
activation of the unfolded protein response (UPR), which intersects with many different
inflammatory and stress signaling pathways. These pathways are also critical in chronic
metabolic diseases such as obesity, insulin resistance, and type 2 diabetes. The ER and
related signaling networks are emerging as a potential site for the intersection of …
The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's adaptive capacity results in activation of the unfolded protein response (UPR), which intersects with many different inflammatory and stress signaling pathways. These pathways are also critical in chronic metabolic diseases such as obesity, insulin resistance, and type 2 diabetes. The ER and related signaling networks are emerging as a potential site for the intersection of inflammation and metabolic disease.
cell.com