Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
M Mogi, M Harada, P Riederer, H Narabayashi… - Neuroscience …, 1994 - Elsevier
M Mogi, M Harada, P Riederer, H Narabayashi, K Fujita, T Nagatsu
Neuroscience letters, 1994•ElsevierTumor necrosis factor-α (TNF-α), a glial-cell-related factor, was measured for the first time in
the brain (striatum) and cerebrospinal fluid (CSF) from control and parkinsonian patients by
a sensitive sandwich enzyme immunoassay. The concentrations of TNF-α in the brain and
CSF were significantly higher in parkinsonian patients than those in controls. Since TNF-α is
an important signal transducer of the immune system with cytotoxic and stimulator
properties, these results suggest that an immune response may occur in the nigrostriatal …
the brain (striatum) and cerebrospinal fluid (CSF) from control and parkinsonian patients by
a sensitive sandwich enzyme immunoassay. The concentrations of TNF-α in the brain and
CSF were significantly higher in parkinsonian patients than those in controls. Since TNF-α is
an important signal transducer of the immune system with cytotoxic and stimulator
properties, these results suggest that an immune response may occur in the nigrostriatal …
Abstract
Tumor necrosis factor-α (TNF-α), a glial-cell-related factor, was measured for the first time in the brain (striatum) and cerebrospinal fluid (CSF) from control and parkinsonian patients by a sensitive sandwich enzyme immunoassay. The concentrations of TNF-α in the brain and CSF were significantly higher in parkinsonian patients than those in controls. Since TNF-α is an important signal transducer of the immune system with cytotoxic and stimulator properties, these results suggest that an immune response may occur in the nigrostriatal dopaminergic regions in Parkinson's disease and that TNF-α may be related, at least in part, to the neuronal degeneration.
Elsevier