Blood-brain barrier permeability during Cuprizone-induced demyelination: Implications for the pathogenesis of immune-mediated demyelinating diseases
DA Bakker, SK Ludwin - Journal of the neurological sciences, 1987 - Elsevier
Blood vessels in the superior cerebellar peduncles were studied in Cuprizone-fed mice for
leakage of proteins into the parenchyma. The status of the blood-brain barrier was
determined at various stages of demyelination both by tracer methods using horseradish
peroxidase and immunochemically using antisera to extravasated serum proteins and was
compared to three positive and negative control conditions. The results showed no evidence
of significant protein leakage into the subendothelial basement membrane or extravascular …
leakage of proteins into the parenchyma. The status of the blood-brain barrier was
determined at various stages of demyelination both by tracer methods using horseradish
peroxidase and immunochemically using antisera to extravasated serum proteins and was
compared to three positive and negative control conditions. The results showed no evidence
of significant protein leakage into the subendothelial basement membrane or extravascular …