Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice
MM Hiremath, Y Saito, GW Knapp, JPY Ting… - Journal of …, 1998 - Elsevier
To study microglial/macrophage infiltration, a cuprizone-induced model for demyelination in
C57BL/6 mice was established. Cuprizone is known to cause demyelination in Swiss mice,
however, cuprizone-induced demyelination in C57BL/6 mice has not been previously
described. Induction of demyelination in C57BL/6 mice enables examination of the function
of microglia/macrophage through comparative analyses of syngeneic mice with various
targeted genetic mutations. In this report, cuprizone-induced demyelination is easily …
C57BL/6 mice was established. Cuprizone is known to cause demyelination in Swiss mice,
however, cuprizone-induced demyelination in C57BL/6 mice has not been previously
described. Induction of demyelination in C57BL/6 mice enables examination of the function
of microglia/macrophage through comparative analyses of syngeneic mice with various
targeted genetic mutations. In this report, cuprizone-induced demyelination is easily …