Gq-dependent signaling upregulates COX2 in glomerular podocytes
L Wang, PJ Flannery, PB Rosenberg… - Journal of the …, 2008 - journals.lww.com
Accumulating evidence suggests that upregulation of cyclooxygenase 2 (COX2) in
glomerular podocytes promotes podocyte injury. Because Gq signaling activates calcineurin
and calcineurin-dependent mechanisms are known to mediate COX2 expression, this study
investigated the role of Gqα in promoting COX2 expression in podocytes. A constitutively
active Gq α subunit tagged with the TAT HIV protein sequence was introduced into an
immortalized podocyte cell line by protein transduction. This stimulated inositol …
glomerular podocytes promotes podocyte injury. Because Gq signaling activates calcineurin
and calcineurin-dependent mechanisms are known to mediate COX2 expression, this study
investigated the role of Gqα in promoting COX2 expression in podocytes. A constitutively
active Gq α subunit tagged with the TAT HIV protein sequence was introduced into an
immortalized podocyte cell line by protein transduction. This stimulated inositol …