Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

M Conrad, JP Friedmann Angeli - Molecular & cellular oncology, 2015 - Taylor & Francis
Molecular & cellular oncology, 2015Taylor & Francis
The system XC−/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls
ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling
evidence has established that this route of cell death is not only of high relevance for
triggering cancer cell death, but also proves to be amenable for therapeutic intervention to
halt ischemia/reperfusion-related diseases.
The system XC/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.
Taylor & Francis Online