[HTML][HTML] Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism1 [S]
R Caesar, H Nygren, M Orešič, F Bäckhed - Journal of lipid research, 2016 - ASBMB
The gut microbiota influences many aspects of host metabolism. We have previously shown
that the presence of a gut microbiota remodels lipid composition. Here we investigated how
interaction between gut microbiota and dietary lipids regulates lipid composition in the liver
and plasma, and gene expression in the liver. Germ-free and conventionally raised mice
were fed a lard or fish oil diet for 11 weeks. We performed lipidomics analysis of the liver and
serum and microarray analysis of the liver. As expected, most of the variation in the …
that the presence of a gut microbiota remodels lipid composition. Here we investigated how
interaction between gut microbiota and dietary lipids regulates lipid composition in the liver
and plasma, and gene expression in the liver. Germ-free and conventionally raised mice
were fed a lard or fish oil diet for 11 weeks. We performed lipidomics analysis of the liver and
serum and microarray analysis of the liver. As expected, most of the variation in the …