Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis—experience from two prospective cohorts
B Kornblit, D Hellemann, L Munthe-Fog, J Bonde… - Immunobiology, 2013 - Elsevier
YKL-40, derived from the CHI3L1 gene, has been associated with outcome of infectious and
inflammatory diseases. We hypothesized that plasma YKL-40 concentrations and CHI3L1
genotype could be used as prognostic biomarkers in the assessment of systemic
inflammatory response syndrome (SIRS) and sepsis. The objective of the study was to
assess the prognostic value of plasma YKL-40 and CHI3L1 genotype in patients with SIRS
and sepsis. Plasma YKL-40 and CHI3L1 genotype (rs4950928) were analyzed at time of …
inflammatory diseases. We hypothesized that plasma YKL-40 concentrations and CHI3L1
genotype could be used as prognostic biomarkers in the assessment of systemic
inflammatory response syndrome (SIRS) and sepsis. The objective of the study was to
assess the prognostic value of plasma YKL-40 and CHI3L1 genotype in patients with SIRS
and sepsis. Plasma YKL-40 and CHI3L1 genotype (rs4950928) were analyzed at time of …
