[HTML][HTML] Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease
MR Starkey, AT Essilfie, JC Horvat, RY Kim… - Mucosal …, 2013 - Elsevier
Deleterious responses to pathogens during infancy may contribute to infection and
associated asthma. Chlamydia respiratory infections in early life are common causes of
pneumonia and lead to reduced lung function and asthma. We investigated the role of
interleukin-13 (IL-13) in promoting early-life Chlamydia respiratory infection, infection-
induced airway hyperresponsiveness (AHR), and severe allergic airway disease (AAD).
Infected infant Il13−/− mice had reduced infection, inflammation, and mucus-secreting cell …
associated asthma. Chlamydia respiratory infections in early life are common causes of
pneumonia and lead to reduced lung function and asthma. We investigated the role of
interleukin-13 (IL-13) in promoting early-life Chlamydia respiratory infection, infection-
induced airway hyperresponsiveness (AHR), and severe allergic airway disease (AAD).
Infected infant Il13−/− mice had reduced infection, inflammation, and mucus-secreting cell …
