A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis
BACKGROUND: Cigarette smoke–induced chronic obstructive pulmonary disease (COPD)
is a life-threatening inflammatory disorder of the lung. The development of effective
therapies for COPD has been hampered by the lack of an animal model that mimics the
human disease in a short timeframe. OBJECTIVES: We sought to create an early-onset
mouse model of cigarette smoke–induced COPD that develops the hallmark features of the
human condition in a short time-frame. We also sought to use this model to better …
is a life-threatening inflammatory disorder of the lung. The development of effective
therapies for COPD has been hampered by the lack of an animal model that mimics the
human disease in a short timeframe. OBJECTIVES: We sought to create an early-onset
mouse model of cigarette smoke–induced COPD that develops the hallmark features of the
human condition in a short time-frame. We also sought to use this model to better …