[HTML][HTML] The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-κB activation at the level of TRAF6

K Heyninck, R Beyaert - FEBS letters, 1999 - Elsevier
K Heyninck, R Beyaert
FEBS letters, 1999Elsevier
The zinc finger protein A20 is encoded by an immediate early response gene whose
expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1). Gene
induction by IL-1 is mediated by activation of the transcription factor NF-κB, and requires the
signal adapter protein TRAF6. The latter interacts with the NF-κB-inducing kinase NIK, which
is believed to be part of the IκB kinase complex. Expression of A20 potently inhibits IL-1-
induced NF-κB activation by an unknown mechanism. Inhibition of IL-1-induced NF-κB …
The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1). Gene induction by IL-1 is mediated by activation of the transcription factor NF-κB, and requires the signal adapter protein TRAF6. The latter interacts with the NF-κB-inducing kinase NIK, which is believed to be part of the IκB kinase complex. Expression of A20 potently inhibits IL-1-induced NF-κB activation by an unknown mechanism. Inhibition of IL-1-induced NF-κB activation was found to be mediated by the C-terminal zinc finger-containing domain of A20. More importantly, we present evidence that A20 interferes with IL-1-induced NF-κB activation at the level of TRAF6, upstream of NIK. Moreover, A20 was shown to directly interact with TRAF6.
Elsevier