Genetic deletion of apolipoprotein AI increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung
W Wang, H Xu, Y Shi, S Nandedkar, H Zhang… - Journal of lipid …, 2010 - ASBMB
The relationship between high-density lipoprotein and pulmonary function is unclear. To
determine mechanistic relationships we investigated the effects of genetic deletion of
apolipoprotein AI (apoA-I) on plasma lipids, paraoxonase (PON1), pro-inflammatory HDL (p-
HDL), vasodilatation, airway hyperresponsiveness and pulmonary oxidative stress, and
inflammation. ApoA-I null (apoA-I−/−) mice had reduced total and HDL cholesterol but
increased pro-inflammatory HDL compared with C57BL/6J mice. Although PON1 protein …
determine mechanistic relationships we investigated the effects of genetic deletion of
apolipoprotein AI (apoA-I) on plasma lipids, paraoxonase (PON1), pro-inflammatory HDL (p-
HDL), vasodilatation, airway hyperresponsiveness and pulmonary oxidative stress, and
inflammation. ApoA-I null (apoA-I−/−) mice had reduced total and HDL cholesterol but
increased pro-inflammatory HDL compared with C57BL/6J mice. Although PON1 protein …
