Epigenetics direct transdifferentiation
BA Purnell - Science Signaling, 2014 - science.org
BA Purnell
Science Signaling, 2014•science.orgTo make an entire animal, many and varied cell types form and interact. Some of these
differentiated cells take a U-turn and can dedifferentiate or transdifferentiate to another cell
fate. Although relatively rare in nature, Zuryn et al. followed such a program in the tiny
roundworm Caenorhabditis elegans, where a rectal cell–to–motor neuron conversion is
seen. Transcription factors with conserved roles in cell plasticity and terminal fate selection
partner up with specific histone-modifying enzymes in discrete steps to specify separate …
differentiated cells take a U-turn and can dedifferentiate or transdifferentiate to another cell
fate. Although relatively rare in nature, Zuryn et al. followed such a program in the tiny
roundworm Caenorhabditis elegans, where a rectal cell–to–motor neuron conversion is
seen. Transcription factors with conserved roles in cell plasticity and terminal fate selection
partner up with specific histone-modifying enzymes in discrete steps to specify separate …
To make an entire animal, many and varied cell types form and interact. Some of these differentiated cells take a U-turn and can dedifferentiate or transdifferentiate to another cell fate. Although relatively rare in nature, Zuryn et al. followed such a program in the tiny roundworm Caenorhabditis elegans, where a rectal cell–to–motor neuron conversion is seen. Transcription factors with conserved roles in cell plasticity and terminal fate selection partner up with specific histone-modifying enzymes in discrete steps to specify separate sequential phases of cell identity.
S. Zuryn, A. Ahier, M. Portoso, E. R. White, M.-C. Morin, R. Margueron, S. Jarriault, Sequential histone-modifying activities determine the robustness of transdifferentiation. Science 345, 826–829 (2014). [Abstract] [Full Text]
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