Ten-eleven translocation-2 (TET2) is a member of the methylcytosine dioxygenase family of
enzymes and has been implicated in cancer and aging because of its role as a global
epigenetic modifier. TET2 has a large N-terminal domain and a catalytic C-terminal region.
Previous reports have demonstrated that the TET2 catalytic domain remains active
independently of the N-terminal domain. As such, the function of the N terminus of this large
protein remains poorly characterized. Here, using yeast two-hybrid screening, co …