Multiple (two to seven) samples, obtained from the same surgical specimen or at different
occasions, were analyzed in 54 benign and malignant soft tissue tumors, to investigate
cytogenetic clonal evolution. In 28 tumors only normal karyotypes were found. Ten tumors
had abnormal karyotypes, but were noninformative, most often due to a high level of
karyotypic complexity or great cell-to-cell variation. Sixteen tumors were informative: four
(leiomyosarcoma, liposarcoma, malignant Schwannoma, and a benign mesenchymal tumor …