[HTML][HTML] Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal …
A Kerstan, E Niebergall-Roth, J Esterlechner… - Cytotherapy, 2021 - Elsevier
Background aim Mesenchymal stromal cells (MSCs) hold promise for the treatment of tissue
damage and injury. However, MSCs comprise multiple subpopulations with diverse
properties, which could explain inconsistent therapeutic outcomes seen among therapeutic
attempts. Recently, the adenosine triphosphate-binding cassette transporter ABCB5 has
been shown to identify a novel dermal immunomodulatory MSC subpopulation. Methods
The authors have established a validated Good Manufacturing Practice (GMP)-compliant …
damage and injury. However, MSCs comprise multiple subpopulations with diverse
properties, which could explain inconsistent therapeutic outcomes seen among therapeutic
attempts. Recently, the adenosine triphosphate-binding cassette transporter ABCB5 has
been shown to identify a novel dermal immunomodulatory MSC subpopulation. Methods
The authors have established a validated Good Manufacturing Practice (GMP)-compliant …
