Role of CD44 and hyaluronic acid (HA) in activation of alloreactive and antigen-specific T cells by bone marrow-derived dendritic cells
Y Do, PS Nagarkatti, M Nagarkatti - Journal of immunotherapy, 2004 - journals.lww.com
In the current study, the role played by hyaluronic acid (HA) and its receptor CD44 on the
activation and functions of dendritic cells (DCs) was investigated. Activation of DCs with HA
enhanced their ability to stimulate allogeneic and antigen (Ag)-specific T cells markedly. HA
treatment upregulated the expression of costimulatory molecules such as CD40, CD80, and
CD86 on DCs. Cell mixing experiments using DC or T cells from CD44 wild-type or CD44
knockout mice as well as blocking studies with anti-CD44 monoclonal antibodies revealed …
activation and functions of dendritic cells (DCs) was investigated. Activation of DCs with HA
enhanced their ability to stimulate allogeneic and antigen (Ag)-specific T cells markedly. HA
treatment upregulated the expression of costimulatory molecules such as CD40, CD80, and
CD86 on DCs. Cell mixing experiments using DC or T cells from CD44 wild-type or CD44
knockout mice as well as blocking studies with anti-CD44 monoclonal antibodies revealed …
