[HTML][HTML] Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in inflammatory and interleukin 4-activated macrophages
B Ruffell, GFT Poon, SSM Lee, KL Brown… - Journal of Biological …, 2011 - ASBMB
CD44 is a cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan
and is involved in processes ranging from leukocyte recruitment to wound healing. In the
immune system, the binding of hyaluronan to CD44 is tightly regulated, and exposure of
human peripheral blood monocytes to inflammatory stimuli increases CD44 expression and
induces hyaluronan binding. Here we sought to understand how mouse macrophages
regulate hyaluronan binding upon inflammatory and anti-inflammatory stimuli. Mouse bone …
and is involved in processes ranging from leukocyte recruitment to wound healing. In the
immune system, the binding of hyaluronan to CD44 is tightly regulated, and exposure of
human peripheral blood monocytes to inflammatory stimuli increases CD44 expression and
induces hyaluronan binding. Here we sought to understand how mouse macrophages
regulate hyaluronan binding upon inflammatory and anti-inflammatory stimuli. Mouse bone …
