Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent …
VJ Philbin, DJ Dowling, LC Gallington, G Cortés… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Newborns have frequent infections and manifest impaired vaccine
responses, motivating a search for neonatal vaccine adjuvants. Alum is a neonatal adjuvant
but might confer a TH2 bias. Toll-like receptor (TLR) agonists are candidate adjuvants, but
human neonatal cord blood monocytes demonstrate impaired TH1-polarizing responses to
many TLR agonists caused by plasma adenosine acting through cyclic AMP. TLR8 agonists,
including imidazoquinolines (IMQs), such as the small synthetic 3M-002, induce adult-level …
responses, motivating a search for neonatal vaccine adjuvants. Alum is a neonatal adjuvant
but might confer a TH2 bias. Toll-like receptor (TLR) agonists are candidate adjuvants, but
human neonatal cord blood monocytes demonstrate impaired TH1-polarizing responses to
many TLR agonists caused by plasma adenosine acting through cyclic AMP. TLR8 agonists,
including imidazoquinolines (IMQs), such as the small synthetic 3M-002, induce adult-level …