MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers

TX Lu, JD Sherrill, T Wen, AJ Plassard, JA Besse… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: The role of microRNAs (miRNAs), a key class of regulators of mRNA
expression and translation, in patients with eosinophilic esophagitis (EoE) has not been
explored. OBJECTIVE: We aimed to identify miRNAs dysregulated in patients with EoE and
assess the potential of these miRNAs as disease biomarkers. METHODS: Esophageal
miRNA expression was profiled in patients with active EoE and those with glucocorticoid-
induced disease remission. Expression profiles were compared with those of healthy control …