Calpain and MARCKS protein regulation of airway mucin secretion
WR Lampe, J Park, S Fang, AL Crews… - Pulmonary pharmacology …, 2012 - Elsevier
Hypersecretion of mucin plays an important role in the pathophysiology of many
inflammatory airway diseases, including asthma, chronic bronchitis, and cystic fibrosis.
Myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been shown to play an
important role in regulation of airway mucin secretion, as peptides analogous to the amino
(N)-terminus of MARCKS attenuate mucin secretion by airway epithelium in vitro and in vivo.
Here, we investigated a potential role for the protease Calpain, a calcium-dependent …
inflammatory airway diseases, including asthma, chronic bronchitis, and cystic fibrosis.
Myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been shown to play an
important role in regulation of airway mucin secretion, as peptides analogous to the amino
(N)-terminus of MARCKS attenuate mucin secretion by airway epithelium in vitro and in vivo.
Here, we investigated a potential role for the protease Calpain, a calcium-dependent …