[HTML][HTML] Deimination of human filaggrin-2 promotes its proteolysis by calpain 1
CY Hsu, J Henry, AA Raymond, MC Méchin… - Journal of Biological …, 2011 - ASBMB
Filaggrin-2 (FLG2), a member of the S100-fused type protein family, shares numerous
features with filaggrin (FLG), a key protein implicated in the epidermal barrier functions. Both
display a related structural organization, an identical pattern of expression and localization
in human epidermis, and proteolytic processing of a large precursor. Here, we tested
whether FLG2 was a substrate of calpain 1, a calcium-dependent protease directly involved
in FLG catabolism. In addition, deimination being critical for FLG degradation, we analyzed …
features with filaggrin (FLG), a key protein implicated in the epidermal barrier functions. Both
display a related structural organization, an identical pattern of expression and localization
in human epidermis, and proteolytic processing of a large precursor. Here, we tested
whether FLG2 was a substrate of calpain 1, a calcium-dependent protease directly involved
in FLG catabolism. In addition, deimination being critical for FLG degradation, we analyzed …