Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3α/β impairs in vivo neural precursor cell proliferation
TY Eom, RS Jope - Biological psychiatry, 2009 - Elsevier
BACKGROUND: Adult neurogenesis augments neuronal plasticity, and deficient
neurogenesis might contribute to mood disorders and schizophrenia and impede treatment
responses. Because these diseases might be associated with inadequately controlled
glycogen synthase kinase-3 (GSK3), we tested whether blocked inhibitory serine-
phosphorylation of GSK3 impairs neurogenesis. METHODS: Neural precursor cell (NPC)
proliferation was measured by dentate gyrus bromodeoxyuridine (BrdU) labeling in …
neurogenesis might contribute to mood disorders and schizophrenia and impede treatment
responses. Because these diseases might be associated with inadequately controlled
glycogen synthase kinase-3 (GSK3), we tested whether blocked inhibitory serine-
phosphorylation of GSK3 impairs neurogenesis. METHODS: Neural precursor cell (NPC)
proliferation was measured by dentate gyrus bromodeoxyuridine (BrdU) labeling in …